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A New Butenolide from the Co-Culture of the Endophyte Irpex lacteus, the Phytopathogenic Nigrospora oryzae, and the Host Dendrobium officinale

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Chemistry of Natural Compounds Aims and scope

In this research, the co-culture of the host plant Dendrobium officinale, the endophyte Irpex lacteus, and the pathogenic Nigrospora oryzae was examined to study the interaction of host and endophytes by the production of metabolite. A rare butenolide, named nigrolactin (1), was isolated and its structure determined by spectral analysis. Compound 1 showed significant antifungal activity against Aspergillus fumigate with MIC of 1 μg/mL. The results showed that the interaction of host-endophyte-phytopathogen in co-culture can induce the production of new antifungal metabolites.

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ACKNOWLEDGMENT

This project was supported by the National Natural Science Foundation of China (81960640, 81660582, and 81560571), projects of the Yunling Scholars of Yunnan Province and Donglu Scholars of Yunnan University, the Program for Changjiang Scholars and Innovative Research Team in University (IRT-17R94), and the Yunnan University′s Research Innovation Fund for Graduate Students (2019z047, 2019188). The NMR and MS spectra were measured at the Advance Analysis and Measurement Center of Yunnan University.

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Authors and Affiliations

  1. Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China

    Shuang Yang, Shuang Su, Rong-Huan Cen, Li-Jingfei Sun, Xue-Qiong Yang, Ya-Bin Yang & Zhong-Tao Ding

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  1. Shuang Yang
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  2. Shuang Su
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  3. Rong-Huan Cen
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  4. Li-Jingfei Sun
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  5. Xue-Qiong Yang
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  6. Ya-Bin Yang
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  7. Zhong-Tao Ding
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Corresponding authors

Correspondence to Xue-Qiong Yang or Ya-Bin Yang.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 350–351.

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Yang, S., Su, S., Cen, RH. et al. A New Butenolide from the Co-Culture of the Endophyte Irpex lacteus, the Phytopathogenic Nigrospora oryzae, and the Host Dendrobium officinale. Chem Nat Compd 58, 404–406 (2022). https://doi.org/10.1007/s10600-022-03693-y

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  • DOI: https://doi.org/10.1007/s10600-022-03693-y

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