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Antinociceptive Diterpenoid Alkaloids from the Roots of Aconitum pseudostapfianum

Phytochemical investigation of the roots of Aconitum pseudostapfianum resulted in the isolation of two new C19-diterpenoid alkaloids, designated as pseudostapines A and B (1 and 2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated alkaloids were tested in vivo for antinociceptive potential. The results show that pseudostapines A and B possess more potent antinociceptive effect than the positive control drugs aspirin and acetaminophen.

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References

  1. H. Niitsu, Y. Fujita, S. Fujita, R. Kumagai, M. Takamiya, Y. Aoki, and K. Dewa, Forensic Sci. Int., 227, 111 (2013).

    CAS  Article  Google Scholar 

  2. J. Singhuber, M. Zhu, S. Prinz, and B. Kopp, J. Ethnopharmacol., 126, 18 (2009).

    Article  Google Scholar 

  3. A. Bello-Ramirez, J. Buendia-Orozco, and A. Nava-Ocampo, Fund. Clin. Pharmacol., 17, 575 (2003).

    CAS  Article  Google Scholar 

  4. T. Yamamoto, K. Yuyama, K. Nakamura, T. Kato, and H. Yamamoto, Eur. J. Pharmacol., 397, 25 (2000).

    CAS  Article  Google Scholar 

  5. J. Li, W. Ren, X. J. Huang, D. J. Zou, and X. Hu, Brain Res. Bull., 97, 81 (2013).

    CAS  Article  Google Scholar 

  6. T. Kiss, P. Orvos, S. Bansaghi, P. Forgo, N. Jedlinszki, L. Talosi, J. Hohmann, and D. Csupor, Fitoterapia, 90, 85 (2013).

    CAS  Article  Google Scholar 

  7. M. Liang, S. C. Li, B. Shen, J. P. Cai, C. Li, Z. Y. Wang, X. G. Li, J. Gao, H. Y. Huang, X. Y. Zhang, and J. Y. Li, Carbohydr. Polym., 88, 973 (2012).

    CAS  Article  Google Scholar 

  8. D. K. Zhao, H. L. Ai, S. H. Zi, L. M. Zhang, S. C. Yang, H. C. Guo, Y. Shen, Y. P. Chen, and J. J. Chen, Fitoterapia, 91, 280 (2013).

    CAS  Article  Google Scholar 

  9. J. Hu, J. X. Li, Q. Li, X. Mao, T. F. Peng, N. H. Jin, S. Yin, X. D. Shi, and Y. Li, Chem. Nat. Compd., 57, 503 (2021).

    CAS  Article  Google Scholar 

  10. J. G. Diaz, J. G. Ruiza, and W. Herz, Phytochemistry, 66, 837 (2005).

    CAS  Article  Google Scholar 

  11. F. Gao, X. Y. Liu, and F. P. Wang, Helv. Chim. Acta, 93, 785 (2010).

    CAS  Article  Google Scholar 

  12. J. Hu, X. D. Shi, X. Mao, J. G. Chen, L. Zhu, and Q. J. Zhao, J. Ethnopharmacol., 150, 828 (2013).

    CAS  Article  Google Scholar 

Download references

Acknowledgment

The above research was made possible by a grant from the joint special fund project of the Applied Basic Research for Local University in Yunnan Province (2019FH001 (-033)), Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).

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Correspondence to Chong Liu.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 270–272.

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Hu, J., Li, J., Li, Q. et al. Antinociceptive Diterpenoid Alkaloids from the Roots of Aconitum pseudostapfianum. Chem Nat Compd 58, 312–315 (2022). https://doi.org/10.1007/s10600-022-03666-1

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  • DOI: https://doi.org/10.1007/s10600-022-03666-1

Keywords

  • Aconitum pseudostapfianum
  • Ranunculaceae
  • C19-diterpenoid alkaloids
  • antinociceptive activity