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A New Triterpene from Metadina trichotoma

One new triterpene, 6α-hydroxyilexosapogenin A (1), and nine known compounds were isolated from Metadina trichotoma. Their structures were mainly elucidated by NMR and MS spectra. As evidenced by a glucose concentration assay, compound 2 can stimulate glucose uptake in 3T3-L1 adipocytes and is the first pyrocincholic acid type triterpenoid that shows promoting glucose uptake activity.

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References

  1. Delectis Florae Reipublicae Popularis Sinicae Agendae, Academiae Sinicae Edita, Flora Reipublicae Popularis Sinicae, 71, 268 (1999).

    Google Scholar 

  2. Y. M. Zhang, N. H. Tan, H. Q. Huang, and G. Z. Zeng, Z. Naturforsch. C, 62, 745 (2007).

    CAS  Article  Google Scholar 

  3. J. Cinatal, B. Morgenstern, G. Bauer, P. Chandra, H. Rabenau, and H. W. Doerr, Lancet, 361, 045 (2003).

    Article  Google Scholar 

  4. F. Guan, Q. Wang, M. Wang, Y. Shan, Y. Chen, M. Yin, Y. Zhao, X. Feng, F. Liu, and J. Zhang, Molecules, 20, 6419 (2015).

    CAS  Article  Google Scholar 

  5. P. Bernard, T. Scior, B. Didier, M. Hibert, and J. Y. Berthon, Phytochemistry, 58, 865 (2001).

    CAS  Article  Google Scholar 

  6. V. Ramachandran and R. Saravanan, J. Funct. Foods, 5, 1077 (2013).

    CAS  Article  Google Scholar 

  7. L. Peng, Y. Lu, Y. Xu, J. Hu, F. Wang, Y. Zhang, and W. Xiong, Nat. Prod. Bioprospect., 7, 225 (2017).

    CAS  Article  Google Scholar 

  8. K. Amimoto, K. Yoshikawa, and S. Arihara, Chem. Pharm. Bull., 41, 77 (1993).

    CAS  Article  Google Scholar 

  9. A. Rumbero-Sanchez and P. Vazquez, Phytochemistry, 30, 311 (1991).

    CAS  Article  Google Scholar 

  10. T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, H. Gunji, and K. Irie, J. Nat. Prod., 79, 2521 (2016).

    CAS  Article  Google Scholar 

  11. D. Peng, X. Lin, L. Jiang, J. Huang, G. Zeng, X. Deng, and Y. Zhou, Nat. Prod. Res., 33, 427 (2018).

    Article  Google Scholar 

  12. H. Kobayashi, H. Karasawa, T. Miyase, and S. Fukushima, Chem. Pharm. Bull., 32, 1452 (1985).

    Article  Google Scholar 

  13. M. Dudas, M. Vilkova, T. Beres, M. Repcak, and P. Martonfi, Nat. Prod. Commun., 11, 837 (2016).

    PubMed  Google Scholar 

  14. M. Ono, N. C. Ishimatsu, H. Yoshimitsu, R. Tsuchihashi, M. Okawa, J. Kinjo, T. Ikeda, and T. Nohara, Chem. Pharm. Bull., 55, 632 (2007).

    CAS  Article  Google Scholar 

  15. K. Machida, E. Takehara, H. Kobayashi, and M. Kikuchi, Chem. Pharm. Bull., 51, 1417 (2003).

    CAS  Article  Google Scholar 

  16. M. Ono, M. Ueno, C. Masuoka, T. Ikeda, and T. Nohara, Chem. Pharm. Bull., 53, 1342 (2005).

    CAS  Article  Google Scholar 

  17. M. Kuroyanagi, M. Shiotsu, T. Ebihara, H. Kawai, A. Ueno, and S. Fukushima, Chem. Pharm. Bull., 34, 4012 (1986).

    CAS  Article  Google Scholar 

  18. R. Govers, A. C. Coster, and D. E. James, Mol. Cell. Biol., 24, 6456 (2004).

    CAS  Article  Google Scholar 

  19. S. C. Frost and M. D. Lane, J. Biol. Chem., 260, 2646 (1985).

    CAS  Article  Google Scholar 

  20. L. Zhou, Y. Yang, X. Wang, S. Liu, W. Shang, G. Yuan, F. Li, J. Tang, M. Chen, and J. Chen, Metabolism, 56, 405 (2007).

    CAS  Article  Google Scholar 

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ACKNOWLEDGMENT

This investigation was supported by grants from the Institute of Drug Innovation of the Chinese Academy of Sciences (Grant No. CASIMM0520181002), and the Special Project for Environmental Protection in Yunnan Province (Grant No. E1YN051K).

Binbin Fan and Jiaxiang Liu contributed equally to this work.

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Correspondence to Yu-Mei Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 258–260.

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Fan, BB., Liu, JX., Hu, HJ. et al. A New Triterpene from Metadina trichotoma. Chem Nat Compd 58, 297–300 (2022). https://doi.org/10.1007/s10600-022-03663-4

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  • DOI: https://doi.org/10.1007/s10600-022-03663-4

Keywords

  • Metadina trichotoma
  • triterpenoid
  • 3T3-L1 adipocytes
  • glucose uptake