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A New Triterpene from Metadina trichotoma

One new triterpene, 6α-hydroxyilexosapogenin A (1), and nine known compounds were isolated from Metadina trichotoma. Their structures were mainly elucidated by NMR and MS spectra. As evidenced by a glucose concentration assay, compound 2 can stimulate glucose uptake in 3T3-L1 adipocytes and is the first pyrocincholic acid type triterpenoid that shows promoting glucose uptake activity.

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This investigation was supported by grants from the Institute of Drug Innovation of the Chinese Academy of Sciences (Grant No. CASIMM0520181002), and the Special Project for Environmental Protection in Yunnan Province (Grant No. E1YN051K).

Binbin Fan and Jiaxiang Liu contributed equally to this work.

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Correspondence to Yu-Mei Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 258–260.

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Fan, BB., Liu, JX., Hu, HJ. et al. A New Triterpene from Metadina trichotoma. Chem Nat Compd 58, 297–300 (2022).

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  • Metadina trichotoma
  • triterpenoid
  • 3T3-L1 adipocytes
  • glucose uptake