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A New Triterpene from Metadina trichotoma

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Chemistry of Natural Compounds Aims and scope

One new triterpene, 6α-hydroxyilexosapogenin A (1), and nine known compounds were isolated from Metadina trichotoma. Their structures were mainly elucidated by NMR and MS spectra. As evidenced by a glucose concentration assay, compound 2 can stimulate glucose uptake in 3T3-L1 adipocytes and is the first pyrocincholic acid type triterpenoid that shows promoting glucose uptake activity.

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ACKNOWLEDGMENT

This investigation was supported by grants from the Institute of Drug Innovation of the Chinese Academy of Sciences (Grant No. CASIMM0520181002), and the Special Project for Environmental Protection in Yunnan Province (Grant No. E1YN051K).

Binbin Fan and Jiaxiang Liu contributed equally to this work.

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Authors and Affiliations

  1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 650223, Kunming, P. R. China

    Bin-Bin Fan, Jia-Xiang Liu & Yu-Mei Zhang

  2. University of Chinese Academy of Sciences, 100049, Beijing, P. R. China

    Bin-Bin Fan, Jia-Xiang Liu & Hai-Jun Hu

  3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, P. R. China

    Hai-Jun Hu

Authors
  1. Bin-Bin Fan
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  2. Jia-Xiang Liu
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  3. Hai-Jun Hu
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  4. Yu-Mei Zhang
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Corresponding author

Correspondence to Yu-Mei Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 258–260.

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Fan, BB., Liu, JX., Hu, HJ. et al. A New Triterpene from Metadina trichotoma. Chem Nat Compd 58, 297–300 (2022). https://doi.org/10.1007/s10600-022-03663-4

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  • DOI: https://doi.org/10.1007/s10600-022-03663-4

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