Skip to main content

Two New Sesquiterpenes from the Stems of Fissistigma maclurei

Two new sesquiterpenes, 7-hydroxy-15-nor-α-cadin-4-one (1) and 15-nor-α-cadin-4-one (2), together with six known sesquiterpenes (3–8), were isolated from the stems of Fissistigma maclurei Merr. Their structures were elucidated using comprehensive spectroscopic methods. All compounds were evaluated on their anti-inflammatory activities via testing the inhibitory activities against nitric oxide (NO) production induced by lipopolysaccharides in mouse macrophage RAW 264.7 cells in vitro.

This is a preview of subscription content, access via your institution.

Fig. 1


  1. SFDA, in: Chinese Herbal Medicine, Vol. 3, Shanghai Science and Technology Publishing Co., Shanghai, 1997, pp. 1594–1595.

  2. X. M. Zhou, C. J. Zheng, Y. Q. Zhang, X. P. Zhang, X. P. Song, W. Xu, and G. Y. Chen, Planta Med., 83, 217 (2017).

    CAS  PubMed  Google Scholar 

  3. J. De Pascual Teresa, M. A. Moreno Valle, M. S. Gonzalez, and I. S. Bellido, Tetrahedron, 40, 2189 (1984).

    Article  Google Scholar 

  4. Y. H. Kuo, C. H. Chen, S. C. Chien, and Y. L. Lin, J. Nat. Prod., 65, 25 (2002).

    CAS  Article  Google Scholar 

  5. T. Matsumoto, S. Nakamura, S. Nakashima, K. Fujimoto, M. Yoshikawa, T. Ohta, K. Ogawa, and H. Matsuda, J. Nat. Prod., 77, 990 (2014).

    CAS  Article  Google Scholar 

  6. T. Huang, S. H. Ying, J. Y. Li, H. W. Chen, Y. Zang, W. X. Wang, J. Li, J. Xiong, J. F. Hu, Phytochemistry, 169, 112184 (2020).

    CAS  Article  Google Scholar 

  7. L. Hou, G. Ding, B. L. Guo, W. H. Huang, X. J. Zhang, Z. Y. Sun, and X. F. Shi, Molecules, 20, 1551 (2015).

    Article  Google Scholar 

  8. J. Cai, X. M. Zhou, X. Yang, M. M. Tang, Q. Y. Liao, B. Z. Meng, S. Liao, and G. Y. Chen, Bioorg. Chem., 94, 033622020 (2020).

    Google Scholar 

  9. T. Mosmann, J. Immunol. Meth., 65, 55 (1983).

    CAS  Article  Google Scholar 

Download references


This work was supported by the Hainan Province Natural Science Foundation (218QN234), the National Natural Science Foundation of China (21662012 and 41866005), the Hainan Province Natural Science Foundation of Innovative Research Team Project (2016CXTD007), and the Innovative Research Team Project of Ministry (IRT-16R19).

Author information

Authors and Affiliations


Corresponding author

Correspondence to Xue-Ming Zhou.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 244–246.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Luo, YX., Wu, Y., Dai, DC. et al. Two New Sesquiterpenes from the Stems of Fissistigma maclurei. Chem Nat Compd 58, 279–282 (2022).

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI:


  • Fissistigma maclurei
  • sesquiterpene
  • norisoprenoid
  • anti-inflammatory activities