Two new benzo[c]azepin-1-ones, 2,3-dihydro-8-(3-hydroxypropyl)-4-methoxy-7-methylbenzo[c]azepin-1- one (1) and 2,3-dihydro-6-(hydroxymethyl)-8-(3-hydroxypropyl)-4-methoxybenzo[c]azepin-1-one (2), were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds had high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.
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Acknowledgment
This project was supported financially by the Foundation of China Tobacco Company (110201901021 (JY-08)), the National Natural Science Foundation of China (No. 21762050), the Foundation of Yunnan Tobacco Industry Co., Ltd. (No. 2019JC04), and the Yunnan Innovative Research Team (2019HC020).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 223–226.
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Zhou, T., Gao, Q., Mi, QL. et al. Two New Benzo[C]Azepin-1-Ones from Whole Plants of Thalictrum glandulosissimum and their Antibacterial Activity. Chem Nat Compd 58, 254–257 (2022). https://doi.org/10.1007/s10600-022-03653-6
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DOI: https://doi.org/10.1007/s10600-022-03653-6