A series of new N-((4,5,7-trimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methylene)formohydrazide derivatives was synthesized through the coupling of hydrazide compound and emodin formaldehyde obtained by a four-step procedure starting from emodin. The Vibrio harveyi inhibition activity of the newly prepared compounds was evaluated. Results revealed that all compounds showed different degrees of Vibrio harveyi inhibition. Among them, compound 7e showed the best inhibition zone diameter and the most potent Vibrio harveyi inhibitory activity.
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Acknowledgment
This work was supported by the Postgraduate Research and Practice Innovation Programme of Jiangsu Province (KYCX20-2894, KYCX20-2897, and SJCX20-1212), a Project Funded by the Priority Academic Programme Development of Jiangsu Higher Education Institutions (PAPD), the Natural Science Foundation of Jiangsu Province (BK20151281), and the State Special Research Project for Marine Public Welfare Industry (201505023).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 195–198.
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Shao, ZB., Jiang, KJ., Cao, LG. et al. Synthesis of Emodin Acylhydrazone Derivatives and Determination of Vibrio harveyi Inhibitory Activity. Chem Nat Compd 58, 222–226 (2022). https://doi.org/10.1007/s10600-022-03645-6
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DOI: https://doi.org/10.1007/s10600-022-03645-6