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Structure of Gleditsia triacanthos Galactomannan and Its Use in a Hemodynamic Blood Substitute Composition

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Chemistry of Natural Compounds Aims and scope

A water-soluble depolymerized galactomannan (DGM) polysaccharide with MM 18 kDa and Gal–Man monosaccharide ratio 1:2.1 was obtained from Gleditsia triacanthos seeds. The structure of DGM was established using methylation and 1H and 13C NMR spectroscopy as (1→6)-α-D-galactopyranosyl-(1→4)-β-D-mannan. Pharmacological studies showed that the galactomannan was a constituent of the polyfunctional hemodynamic blood substitute rheoambrasol with hemodynamic, antiacid, and antioxidant activity for hemorrhagic shock.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

    R. K. Rakhmanberdyeva & O. Sh. Boimatov

  2. Republican Specialized Scientific Practical Medical Center of Hematology, Ministry of Health, Tashkent, Republic of Uzbekistan, Uzbekistan

    L. I. Shevchenko & Zh. D. Khuzhakhmedov

Authors
  1. R. K. Rakhmanberdyeva
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  2. L. I. Shevchenko
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  3. O. Sh. Boimatov
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  4. Zh. D. Khuzhakhmedov
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Correspondence to R. K. Rakhmanberdyeva.

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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 179–182.

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Rakhmanberdyeva, R.K., Shevchenko, L.I., Boimatov, O.S. et al. Structure of Gleditsia triacanthos Galactomannan and Its Use in a Hemodynamic Blood Substitute Composition. Chem Nat Compd 58, 203–207 (2022). https://doi.org/10.1007/s10600-022-03641-w

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  • DOI: https://doi.org/10.1007/s10600-022-03641-w

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