A new phenanthrene, 2,3,7-trihydroxy-4,8-dimethoxyphenanthrene (1), was isolated from Pleione maculata. Its structure was determined on the basis of NMR (1D and 2D) and HR-ESI-MS data. The new compound was also evaluated for its α-glucosidase inhibitory activity. Compared with the positive control, the new compound even slightly exceeded the effect of acarbose.
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Acknowledgment
The research work was supported by the Program Innovative Research Team in Science and Technology in Yunnan Province (No. 202005AE160004), the Foundation of Yunling Scholars in Yunnan Province (2019); Special projects in Yunnan Province (No. 202002AA100007), Discipline construction platform of Yunnan University of Traditional Chinese Medicine (2020), the sub-project National key research and development (No. 2018YFC0807201-4), the National Natural Science Foundation of China (No. 21202066), the Applied Basic Research Program of Yunnan Province [No. 2017 FE468 (-025)], and the Project for Excellent Young Teacher of Kunming Medical University (Nos. J130130661, 60118090145, and 6011521120).
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2022, pp. 10–12.
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Li, YP., Chen, YP., Chen, XL. et al. A New Phenanthrene Derivative with α-Glucosidase Inhibitory Activity from Pleione maculata. Chem Nat Compd 58, 6–8 (2022). https://doi.org/10.1007/s10600-022-03587-z
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DOI: https://doi.org/10.1007/s10600-022-03587-z