A series of novel L-pyroglutamate containing 1,2,3-triazole ring substructures was synthesized and characterized by adopting an appropriate synthetic scheme. The effect of different substituents on the triazole ring at the ortho-, meta- and para-positions of the benzene ring was evaluated for the inhibition of zoospore release activity against Phytophthora infestans. Among the triazole analogs of L-pyroglutamate, compounds with a phenyl or benzyl group on the triazole ring at the meta-position of the benzene ring showed potent antifungal activity. Results indicated that some of the L-pyroglutamic acid derivatives possessed antifungal activity against Phytophthora infestans.
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This work was supported financially by the National Natural Science Foundation of China (21977083).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 926–929.
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Sun, M., Han, L., Li, A. et al. Design, Synthesis, and Evaluation of Novel L-Pyroglutamic Acid Derivatives as Potent Antifungal Agents. Chem Nat Compd 57, 1081–1085 (2021). https://doi.org/10.1007/s10600-021-03553-1
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DOI: https://doi.org/10.1007/s10600-021-03553-1