New lappaconitine, N-deacetyllappaconitine, and lappaconine derivatives with C-19 C–C-bonded substituents were prepared from lappaconitine–isoxazolidine hybrids by reductive and oxidative opening of isoxazolidine rings annelated to the lappaconitine N(20)–C(19) bond.
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The work was financially supported by RSF Grant No. 19-13-00096.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 913–919.
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Tsyrlina, E.M., Gabbasov, T.M., Spirikhin, L.V. et al. New C-19-Substituted Lappaconitine Derivatives. Chem Nat Compd 57, 1066–1073 (2021). https://doi.org/10.1007/s10600-021-03551-3
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DOI: https://doi.org/10.1007/s10600-021-03551-3