A new acenaphthylene derivative, salviarisanal (1), has been isolated from the aerial part of Salvia arisanensis, together with six known compounds, carnosol (2), 16-hydroxycarnosol (3), ferruginol (4), cryptotanshinone (5), salvileucantholide (6), and dugesin B (7). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, cryptotanshinone (5) exhibited cytotoxicities with IC50 values of 5.38, 7.16, 4.84, and 9.10 μM, respectively, against DLD-1, CCRF-CEM, HL-60, and IMR-32 cell lines. 16-Hydroxycarnosol (3) also exhibited cytotoxicities with IC50 values of 7.42 and 6.73 μM, respectively, against DLD-1 and IMR-32 cell lines. In addition, salviarisanal (1), carnosol (2), 16-hydroxycarnosol (3), and ferruginol (4) showed potent inhibition with IC50 values of 18.45, 30.33, 27.58, and 35.05 μM, respectively, against LPS-induced NO generation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. C. Huang, T. H. Hsieh, and W. T. Cheng, Labiatae in Flora of Taiwan, Vol. 4, 2nd Ed., Editorial Committee of the Flora of Taiwan, Taipei, Taiwan, 1998, pp. 432–548.
Y. B. Wu, Z. Y. Ni, Q. W. Shi, M. Dong, H. Kiyota, Y. C. Gu, and B. Cong, Chem. Rev., 112, 5967 (2012).
L. L. Tlacomulco-Flores, M. Deciga-Campos, M. E. Gonzalez-Trujano, A. I. Carballo-Villalobos, and F. Pellicer, J. Ethnopharmacol., 248, 112276 (2020).
Z. K. Yin, Z. M. Feng, J. S. Jiang, X. Zhang, P. C. Zhang, and Y. N. Yang, RSC Adv., 10, 14235 (2020).
X. J. Jiang, X. M. Li, L. X. Wang, S. Z. Wen, G. Z. Wei, K. Yang, and F. Wang, J. Asian Nat. Prod. Res., 22, 989 (2020).
I. C. Guerrero, L. S. Andres, L. G. Leon, R. P. Machin, J. M. Padron, J. G. Luis, and J. Delgadillo, J. Nat. Prod., 69, 1803 (2006).
A. Ulubelen, S. Oksuz, G. Topcu, A. C. Goren, and W. Voelter, J. Nat. Prod., 64, 549 (2001).
B. Esquivel, J. S. Calderon, E. Flores, A. A. Sanchez, and R. Rosas Rivera, Phytochemistry, 46, 531 (1997).
B. Esquivel, R. M. Dominguez, S. Hernandez-Ortega, R. A. Toscano, and L. Rodriguez-Hahn, Tetrahedron, 50, 11593 (1994).
G. Xu, L. Peng, X. Niu, Q. Zhao, R. Li, and H. Sun, Helv. Chim. Acta, 87, 949 (2004).
T. Mosmann, J. Immunol. Methods, 65, 55 (1983).
M. Johansson, B. Kopcke, H. Anke, and O. Sterner, J. Antibiot., 55, 104 (2002).
Acknowledgment
This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from the Cheng Hsin General Hospital (CY10919) and Yuan′s General Hospital (YGH 21-010). We gratefully thank Ms Shou-Ling Huang and Dr. Iren Wang for assistance in the NMR experiments at the Instrumentation Center at NTU, which is supported by the Ministry of Science and Technology, Taiwan. Chien-Ming Huang, Chun-Hao Chang, Chang-Syun Yang, and Chien-Liang Lin have contributed equally to this manuscript.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 851–854.
Rights and permissions
About this article
Cite this article
Huang, CM., Chang, CH., Yang, CS. et al. A New Acenaphthylene and Bioactive Constituents of Salvia arisanensis. Chem Nat Compd 57, 991–995 (2021). https://doi.org/10.1007/s10600-021-03535-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10600-021-03535-3