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24-Epimarkhacanasin C, An Epimeric Cycloartane-Type Triterpenoid from the Leaves of Markhamia stipulata var. canaense

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Chemistry of Natural Compounds Aims and scope

One new cycloartane-type triterpenoid, named 24-epimarkhacanasin C (1), together with four known flavonoids, apigenin (2), luteolin (3), apigenin 7-O-β-D-glucopyranoside (4), and luteolin 7-O-β-Dglucopyranoside (5), was isolated by various chromatographic methods from the ethyl acetate extract of Markhamia stipulata var. canaense leaves. Their structures were elucidated by IR, UV, HR-ESI-MS, and NMR experiments. All compounds were reported for the first time from this species. Their cytotoxicities were evaluated against human breast cancer cell line (MCF-7) by SRB assay. The isolated compounds 1, 3, and 4 exhibited significant cytotoxic activity (IC50 ranged from 53.38 to 68.32 μg/mL), while compounds 2 and 5 did not show activity.

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Correspondence to Tan Phat Nguyen.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 748–750.

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Ngo, T.N., Nguyen, N.T.L., Phan, N.M. et al. 24-Epimarkhacanasin C, An Epimeric Cycloartane-Type Triterpenoid from the Leaves of Markhamia stipulata var. canaense. Chem Nat Compd 57, 875–878 (2021). https://doi.org/10.1007/s10600-021-03501-z

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  • DOI: https://doi.org/10.1007/s10600-021-03501-z

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