A new coumarin derivative, 7-O-methylparamicoumarin A (1), has been isolated from the roots of Chionanthus retusus, together with seven known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (3), quercetin (4), and apigenin (5) exhibited cytotoxicities with IC50 values of 13.69 ± 1.10, 10.41 ± 0.79, and 12.25 ± 0.91 μM, respectively, against DLD-1 cell line. Luteolin (3), quercetin (4), and apigenin (5) also exhibited cytotoxicities with IC50 values of 15.35 ± 1.24, 13.52 ± 0.87, and 19.48 ± 1.26 μM, respectively, against CCRF-CEM cell line. In addition, kaempferol (2), apigenin (5), 3,3′,5,5′,7-pentahydroxyflavanone (6), and oleuropein (8) showed potent inhibition with IC50 values of 24.84 ± 1.95, 27.18 ± 1.82, 25.18 ± 2.07, and 28.14 ± 1.66 μM, respectively, against LPS-induced NO generation.
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Acknowledgment
This research was supported by a grant from Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3), awarded to Prof. J.-J. Chen. This work was also supported by the grants from Kaohsiung Veterans General Hospital Tainan Branch (VHYK109-01) and Pingtung Christian Hospital (PS109030). We gratefully thank Ms Shou-Ling Huang and Dr. Iren Wang for assistance in the NMR experiments of the Instrumentation Center at NTU, which is supported by the Ministry of Science and Technology, Taiwan. I-Chou Wang and Li-Chai Chen have contributed equally to this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 716–719.
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Wang, IC., Chen, LC., Chang, TH. et al. New Coumarin and Bioactive Constituents of Chionanthus retusus. Chem Nat Compd 57, 835–839 (2021). https://doi.org/10.1007/s10600-021-03492-x
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DOI: https://doi.org/10.1007/s10600-021-03492-x