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A New Anthraquinone-Aurone Adduct with Hepatoprotective Activity from the Fruits of Cucumis bisexualis

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Chemistry of Natural Compounds Aims and scope

A previously undescribed anthraquinone-aurone adduct 1, named 8-(4′-hydroxy-3′,5′-dimethoxyphenyl)-12-hydroxy-7-(6′′,7′′-dimethylfuran-2′′-one)-9,16-anthraquinone-furochromene-3,2′′-dione, was isolated from the fruits of Cucumis bisexualis. Its structure was determined by comprehensive spectroscopic data and references. Compound 1 was evaluated for its inhibitory effect against the increase in AST and ALT levels in H2O2-induced HepG2 cells in the range of their maximum nontoxic concentration. Compound 1 exhibited moderate hepatoprotective activities in vitro.

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ACKNOWLEDGMENT

This study was supported by Jiangxi Provincial Natural Science Foundation (20202BAB206078).

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Authors and Affiliations

  1. Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Qinge Ma & Rongrui Wei

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  1. Qinge Ma
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  2. Rongrui Wei
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Correspondence to Rongrui Wei.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2021, pp. 711–713.

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Ma, Q., Wei, R. A New Anthraquinone-Aurone Adduct with Hepatoprotective Activity from the Fruits of Cucumis bisexualis. Chem Nat Compd 57, 828–831 (2021). https://doi.org/10.1007/s10600-021-03490-z

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  • DOI: https://doi.org/10.1007/s10600-021-03490-z

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