Two new (1 and 2) compounds, together with five known (3–7) chromone derivatives, were isolated from the whole plants of Cassia pumila. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–7 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1, 2, 5, and 6 showed good inhibition with IZD of 13.4 ± 2.5, 12.2 ± 2.0, 14.6 ± 2.2, and 14.2 ± 2.6 mm, and compounds 3, 4, and 7 showed weak inhibition with IZD of 10.7 ± 2.2, 11.3 ± 2.0, and 10.8 ± 2.1 mm, respectively.
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ACKNOWLEDGMENT
This project was supported financially by the Foundation of China Tobacco Company (110201901021 (JY-08)), the Yunnan Applied Basic Research Projects for Excellent Young Scholars (2019HB016), the National Natural Science Foundation of China (No. 21562044), and the Yunnan Innovative Research Team (2019HC020).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2021, pp. 370–373.
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Mi, QL., Kong, WS., Li, YK. et al. Chromone Derivatives Of Cassia pumila and their Anti-MRSA Activity. Chem Nat Compd 57, 432–435 (2021). https://doi.org/10.1007/s10600-021-03381-3
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DOI: https://doi.org/10.1007/s10600-021-03381-3