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Antibacterial Naphthalene Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis fukushii

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Chemistry of Natural Compounds Aims and scope

Two new naphthalene derivatives, 1-(3-hydroxy-1-(hydroxymethyl)-2-methoxy-6-methylnaphthalen-7-yl) propan-2-one (1) and 1-(3-hydroxy-1-(hydroxymethyl)-6-methylnaphthalen-7-yl)propan-2-one (2), together three known naphthalene derivatives (3–5) were isolated from the fermentation products of the endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1 and 2 showed weak inhibition with IZD of 10.2 ± 1.8 and 11.3 ± 2.0 mm, respectively.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (No. 21967021), the Foundation of Yunnan Tobacco Industry Co., Ltd. (No. 2019JC04), and the Foundation of Yunnan Innovative Research Team.

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Authors and Affiliations

  1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Xue-Mei Li, Qi-Li Mi, Qian Gao, Jing Li, Chun-Man Song, Wan-Li Zeng, Hai-Ying Xiang, Xin Liu, Jian-Hua Chen, Cheng-Ming Zhang, Guang-Yu Yang, Qiu-Fen Hu & Zhang-Yu Chen

  2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, 650031, Kunming, P. R. China

    Qi-Li Mi & Qiu-Fen Hu

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  1. Xue-Mei Li
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  12. Qiu-Fen Hu
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  13. Zhang-Yu Chen
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Correspondence to Qiu-Fen Hu or Zhang-Yu Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2021, pp. 252–255.

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Li, XM., Mi, QL., Gao, Q. et al. Antibacterial Naphthalene Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis fukushii. Chem Nat Compd 57, 293–296 (2021). https://doi.org/10.1007/s10600-021-03340-y

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  • DOI: https://doi.org/10.1007/s10600-021-03340-y

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