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Two New 5-Oxomilbemycins Possessing an Unusual 3,27-Epoxy Bond from the Genetically Engineered Strain Streptomyces bingchenggensis BCJ60

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Chemistry of Natural Compounds Aims and scope

Two undescribed milbemycin derivatives, milbemycin P (1) and milbemycin Q (2), were isolated from a culture of the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. Their acaricidal and nematocidal activities against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1–2 possessed potent acaricidal and nematocidal activities.

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Acknowledgment

This work was supported by the Science and Technology Project of Taizhou (1801gy24), the Zhejiang Provincial Natural Science Foundation of China (HX2019069 and HX2019078), and the Key Research and Development Program of Zhejiang Province (2020C02028 and 2019C02030).

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Authors and Affiliations

  1. Institute of Applied Biotechnology, School of Medicine and Pharmaceutical Engineering, Taizhou Vocational and Technical College, 318000, Taizhou, P. R. China

    Zhi-Kui Hao & Jian-Song Li

  2. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, 313000, Huzhou, P. R. China

    Ji-Dong Wang

  3. Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, 150000, Harbin, P. R. China

    Wen-Sheng Xiang & Hai-Yan Wang

Authors
  1. Zhi-Kui Hao
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  2. Jian-Song Li
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  3. Ji-Dong Wang
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  4. Wen-Sheng Xiang
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  5. Hai-Yan Wang
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Corresponding authors

Correspondence to Jian-Song Li or Ji-Dong Wang.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2021, pp. 249–251.

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Hao, ZK., Li, JS., Wang, JD. et al. Two New 5-Oxomilbemycins Possessing an Unusual 3,27-Epoxy Bond from the Genetically Engineered Strain Streptomyces bingchenggensis BCJ60. Chem Nat Compd 57, 289–292 (2021). https://doi.org/10.1007/s10600-021-03339-5

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  • DOI: https://doi.org/10.1007/s10600-021-03339-5

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