A New Phenolic Glycoside from Polygonatum Sibiricum and its α-Glucosidase Inhibitory Activity

A new phenolic glycoside 1, together with two known compounds (2, 3), has been isolated from the ethanolic extract of Polygonatum sibiricum F. Delaroche. Its structure was elucidated as (2R)-syringylpropane-1,3-diol-1-O-β-D-glucopyranoside by spectroscopic data (1H NMR, 13C NMR, HSQC, HMBC, and HR-ESI-MS) and chemical evidence. In the in vitro assay, compound 1 displayed potent inhibitory activity against α-glucosidase with an IC50 value of 10.90 μM.

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Fig. 1.


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This work was supported by the National Natural Science Foundation of China (No. 31201563).

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Correspondence to Chun-Chao Zhao.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2021, pp. 43–44.

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Chen, ZY., Liu, Y., Zhang, YQ. et al. A New Phenolic Glycoside from Polygonatum Sibiricum and its α-Glucosidase Inhibitory Activity. Chem Nat Compd 57, 50–52 (2021). https://doi.org/10.1007/s10600-021-03279-0

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  • Liliaceae
  • Polygonatum sibiricum
  • phenolic glycoside
  • α-glucosidase inhibition