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Synthesis of Derivatives of the 2-Arylquinoline Alkaloid Dubamine and their Cytotoxicity

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Chemistry of Natural Compounds Aims and scope

5′-Nitro- (2) and 5′-aminodubamine (3) were sequentially synthesized from the alkaloid dubamine. Condensation of 3 with 15 aldehydes gave imines, reduction of which produced secondary amines. Studies of the cytotoxicities for HeLa and HEp-2 cells of the compounds at a concentration of 100 μM revealed several trends. The activity decreased significantly or disappeared at lower concentrations although compound 5o at concentrations of 1–10 μM was active for HEp-2 cells at the level of cisplatin.

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Acknowledgment

The work was financially supported by the Ministry of Innovative Development, Cabinet of Ministers, Republic of Uzbekistan (Grant MRU-FA-21/2017).

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan

    A. R. Niyazmetov, E. O. Terent’eva, U. B. Khamidova, Z. S. Khashimova, Sh S. Azimova & V. I. Vinogradova

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  1. A. R. Niyazmetov
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  2. E. O. Terent’eva
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  3. U. B. Khamidova
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  4. Z. S. Khashimova
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  5. Sh S. Azimova
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  6. V. I. Vinogradova
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Correspondence to A. R. Niyazmetov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 439–444.

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Niyazmetov, A.R., Terent’eva, E.O., Khamidova, U.B. et al. Synthesis of Derivatives of the 2-Arylquinoline Alkaloid Dubamine and their Cytotoxicity. Chem Nat Compd 56, 511–517 (2020). https://doi.org/10.1007/s10600-020-03074-3

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  • DOI: https://doi.org/10.1007/s10600-020-03074-3

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