Two series of hydrazones were synthesized from 3β-hydroxy- and 3β-(1-adamantoate)-5α-androstan-17- one, respectively, to study the structure–activity relationship. Cytotoxicity studies showed that 5α-androstan- 3β-ol-17-one m-nitrobenzoylhydrazone exhibited pronounced specific activity in a Hoechst experiment against lung carcinoma (A-549) and colorectal adenocarcinoma cell lines (DLD-1).
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2020, pp. 239–241.
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Nadaraia, N.S., Barbakadze, N.N., Mshvildadze, V.D. et al. Synthesis and Cytotoxicity of Epiandrosterone Hydrazones. Chem Nat Compd 56, 274–277 (2020). https://doi.org/10.1007/s10600-020-03005-2
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DOI: https://doi.org/10.1007/s10600-020-03005-2