A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed weak Vibrio harveyi inhibition with MIC values ranging from 16 to 64 μg/mL, whereas 2 was found to be inactive.
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Acknowledgment
We gratefully acknowledge financial support from the National Key Research and Development Program of China (2018YFC0310900), the National Natural Science Foundation of China (41776168, 41706167), the Ningbo Public Service Platform for High-Value Utilization of Marine Biological Resources (NBHY-2017-P2), the Zhejiang Provincial Public Welfare Technology Program (LGC19B020002), the Natural Science Foundation of Ningbo (2018A610320), the Ningbo Sci. & Tech. Projects for Common Wealth (2017C10016), the National 111 Project of China (D16013), the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, and the K. C. Wong Magna Fund in Ningbo University.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2020, pp. 97–99.
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Zhang, L., Qiu, P., Ding, L. et al. A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillus sp. LS53. Chem Nat Compd 56, 109–111 (2020). https://doi.org/10.1007/s10600-020-02955-x
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DOI: https://doi.org/10.1007/s10600-020-02955-x