Steroidal Phytohormone Contents in Several Herbal Blends

  • R. P. LitvinovskayaEmail author
  • A. L. Savchuk
  • M. A. Tomanova
  • V. A. Khripach

Brassinosteroids (BS) are natural low-molecular-mass bioregulators, i.e., plant hormones [1] that are present in all vegetable matter and possess growth-modulating and adaptogenic activity. For example, noticeable growth-stimulating and adaptogenic effects were observed if various agricultural crops were treated with BS at doses of 5–20 mg/hectare. Currently, Epin and Epin Plus, the active ingredients of which are the phytohormones 24-epibrassinolide and 28-homobrassinolide, are the most well-known formulations.

Studies of the effects of BS on animals showed that they could affect reproduction, steroidal hormone balance, and several biochemical and physiological parameters that were clearly indicative of in vivo stimulatory and adaptive changes [2]. The similar activities of BS in plants and non-plants made these compounds potentially valuable for medical applications so the biologically active additive Phytonol based on 24-epibrassinolide was developed [3]; increased work capacity;...



We thank the Belarusian Republic Foundation for Basic Research for financial support.


  1. 1.
    V. A. Khripach, V. N. Zhabinskii, and A. de Groot, Brassinosteroids: A New Class of Plant Hormones, Academic Press, San Diego, 1999, 456 pp.Google Scholar
  2. 2.
    L. A. Nadzharyan, A. M. Voitovich, V. Yu. Afonin, A. I. Kotelenets, and S. E. Ogurtsova, Sovrem. Probl. Toksikol., No. 2, 43 (2006).Google Scholar
  3. 3.
    S. M. Adekenov (ed.), Farm. Byull., No. 3–4, 68 (2015).Google Scholar
  4. 4.
    E. A. Statsenko, Doctoral Dissertation, Federal Scientific Center for Physical Fitness and Sport, Moscow, 2014, 358 pp.Google Scholar
  5. 5.
    V. A. Khripach, R. P. Litvinovskaya, et al., RB Pat. No. 15,826, Feb. 28, 2011; Ofits. Byull. NTsIS RB, No. 2 (2012).Google Scholar
  6. 6.
    C. Romanutti, V. Castilla, and C. E. Coto, Int. J. Antimicrob. Agents, 29, 311 (2007).CrossRefGoogle Scholar
  7. 7.
    J. Ismaili, M. Boisvert, F. Longpre, J. Carange, C. Le Gall, M. G. Martinoli, and B. Daoust, Steroids, 77, 91 (2012).CrossRefGoogle Scholar
  8. 8.
    D. Esposito, P. Kizelsztein, S. Komarnytsky, and I. Raskin, Am. J. Physiol.: Endocrinol. Metab., 303, E652 (2012).Google Scholar
  9. 9.
    V. Khripach, K. Altsivanovich, et al., US Pat. No. 6,998,397, Feb. 14, 2006.Google Scholar
  10. 10.
    A. G. Pradko, R. P. Litvinovskaya, A. L. Sauchuk, S. V. Drach, A. V. Baranovsky, V. N. Zhabinskii, T. V. Mirantsova, and V. A. Khripach, Steroids, 97, 78 (2015).CrossRefGoogle Scholar
  11. 11.
    V. A. Khripach, O. V. Sviridov, A. G. Pryadko, R. P. Litvinovskaya, S. V. Drach, V. D. Matveentsev, and T. V. Novik, Bioorg. Khim., 33, 371 (2007).Google Scholar
  12. 12.
    V. A. Khripach, R. P. Litvinovskaya, S. V. Drach, M. A. Aver′kova, V. N. Zhabinskii, O. V. Sviridov, A. G. Pryadko, and T. V. Novik, Dokl. Nats. Akad. Nauk Belarusi, 53, 74 (2009).Google Scholar
  13. 13.
    V. A. Khripach, R. P. Litvinovskaya, M. E. Raiman, S. V. Drach, V. N. Zhabinskii, O. V. Sviridov, A. G. Pryadko, and T. V. Novik, Vestsi Nats. Akad. Navuk Belarusi, No. 3, 47 (2008).Google Scholar
  14. 14.
    V. Khripach, V. Zhabinskii, V. Antonchick, R. Litvinovskaya, S. Drach, O. Sviridov, A. Pryadko, T. Novik, V. Matveentsev, and B. Schneider, Nat. Prod. Commun., 3, 735 (2008).Google Scholar
  15. 15.
    S. Fujioka, S. Takatsuto, and S. Yoshida, Plant Physiol., 130, 930 (2002).CrossRefGoogle Scholar
  16. 16.
    A. Svatos, A. Antonchick, and B. Schneider, Rapid Commun. Mass Spectrom., 18, 816 (2004).CrossRefGoogle Scholar

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Authors and Affiliations

  • R. P. Litvinovskaya
    • 1
    Email author
  • A. L. Savchuk
    • 1
  • M. A. Tomanova
    • 1
  • V. A. Khripach
    • 1
  1. 1.Institute of Bioorganic ChemistryNational Academy of Sciences of BelarusMinskBelarus

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