A Further Study of the Substrate Constituents of the Fungus Annulohypoxylon boveri var. microspora

  • Ming-Jen ChengEmail author
  • Ming-Der Wu
  • Sung-Yuan Hsieh
  • Hing-Yuen Chan
  • Hsun-Shuo Chang
  • Jih-Jung Chen
  • Yueh-Hsiung Kuo

Endophytes refer to a bacterial (including actinomycete) or fungal microorganism growing in the tissues of their host plants without causing apparent disease symptoms [1, 2, 3]. The host plants offer the endophytes a unique biotope, the growth in which involves continual metabolic interactions with the hosts. Such interactions may enhance the synthesis of secondary metabolites [4]. Hence, endophytes represent an unexplored source of bioactive metabolites. As a result, many fungal endophytes have been cultured and subjected to detailed investigations during the past two decades, which has led to the chemical characterization and biological evaluation of a large number of natural products with novel structures and interesting biological activities [4, 5, 6].

In the course of our studies on secondary metabolites of endophytic fungi from medicinal plants, a fungal strain of Annulohypoxylon boveri var. microsporawas collected from Fu-Shan Botanical Garden, I-lan County, Taiwan. We have...



The author (Yueh-Hsiung Kuo) contributed equally to this work and should both be regarded as first author of this publication. The authors also thank Senior Technician Mrs. Chyi-Jia Wang of the Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University for measuring the 2D NMR data.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ming-Jen Cheng
    • 1
    Email author
  • Ming-Der Wu
    • 1
  • Sung-Yuan Hsieh
    • 1
  • Hing-Yuen Chan
    • 1
  • Hsun-Shuo Chang
    • 2
  • Jih-Jung Chen
    • 3
    • 4
  • Yueh-Hsiung Kuo
    • 5
    • 6
    • 7
  1. 1.Bioresource Collection and Research Center (BCRC)Food Industry Research and Development Institute (FIRDI)HsinchuChina
  2. 2.School of Pharmacy, College of PharmacyKaohsiung Medical UniversityKaohsiungChina
  3. 3.Faculty of Pharmacy, School of Pharmaceutical SciencesNational Yang-Ming UniversityTaipeiChina
  4. 4.Department of Medical ResearchChina Medical University HospitalTaichungChina
  5. 5.Department of Chinese Pharmaceutical Sciences and Chinese Medicine ResourcesChina Medical UniversityTaichungChina
  6. 6.Department of BiotechnologyAsia UniversityTaichungChina
  7. 7.Chinese Medicine Research CenterChina Medical UniversityTaichungChina

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