Two new isobenzofuranone derivatives, 5-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-h]chromen-7(9H)-one (1) and 2,2-dimethyl-5-(2-oxopropyl)-2H-furo[3,4-h]chromen-7(9H)-one (2), were isolated from the fruit of Phyllanthus emblica. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also tested for their antioxidant activity, and they show good antioxidant activity with an IC50 value of 4.5 and 4.2 μg/mL, respectively.
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References
P. T. Li, Flora of China, Vol. 44 (1), 2nd Section., Chinese Science Press, Beijing, 1994, p. 87.
T. K. Lim, Phyllanthus emblica, Edible Medicinal and Non-Medicinal Plants, Springer, Netherlands, 2012, p. 258.
C. B. Deng, Q. J. Xie, and Z. T. Qu, China Pharm., 20, 2120 (2009).
E. A. Poltanov, A. N. Shikov, H. J. D. Dorman, O. N. Pozharitskaya, V. G. Makarov, V. P. Tikhonov, and R. Hiltunen, Phytother Res., 23, 1309 (2009).
Y. J. Zhang, T. Tanaka, C. R. Yang, and I. Kouno, Chem Pharm Bull., 49, 537 (2001).
G. R. She, L. S. Cheng, Y. Xu, R. Shi, L. Zhang, and Y. Guo, Nat. Prod. Commun., 8, 461 (2013).
K. Takara, D. Matsui, K. Wada, T. Ichiba, and Y. Nakasone, Biosci. Biotechnol. Biochem., 66, 29 (2002).
S. Y. Tang, J. L. Shia, C. B. Liu, F. M. Zhang, N. J. Xiang, X. Liu, Y. K. Chen, J. H. You, Q. P. Shen, M. M. Miaoa, Z. H. Liu, and G. Y. Yang, Phytochem. Lett., 19, 60 (2017).
Q. F. Hu, B. Zhou, X. M. Gao, L. Y. Yang, L. D. Shu, Y. Q. Shen, G. P. Li, C. T. Che, and G. Y. Yang, J. Nat. Prod., 75, 1909 (2012).
P. He, P. S. Yanga, S. Y. Tang, L. Ye, C. B. Liu, Q. P. Shen, D. Y. Tang, F. M. Zhang, Z. H. Liu, Y. K. Chen, S. Z. Yao, N. J. Xiang, and Z. J. Huang, Nat. Prod. Res., 31, 2730 (2017).
Q. F. Hu, B. Zhou, X. M. Gao, L. Y. Yang, L. D. Shu, Y. Q. Shen, G. P. Li, C. T. Che, and G. Y. Yang, J. Nat. Prod., 75, 1909 (2012).
S. Takamatsu, A. M. Galal, S. A. Ross, D. Ferreira, M. A. Elsohly, A. R. Ibrahim, and F. S. El-Feraly, Phytother. Res., 17, 963 (2003).
Acknowledgment
This research was supported by the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (No. 2017JC05), the National Natural Science Foundation of China (Nos. 81660717 and 21462051), and the Natural Science Foundation of Yunnan Province (No. 2014FD033).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 730–732.
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Gao, Q., Xiang, HY., Chen, W. et al. Two New Isobenzofuranone Derivatives from Phyllanthus emblica and Their Bioactivity. Chem Nat Compd 55, 847–850 (2019). https://doi.org/10.1007/s10600-019-02829-x
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DOI: https://doi.org/10.1007/s10600-019-02829-x