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Two New Diphenyl Ether Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis asparagi

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Chemistry of Natural Compounds Aims and scope

Two new diphenyl ethers (1 and 2) were isolated from the fermentation products of an endophytic fungus Phomopsis asparagi. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD 10.8 ± 2.0 and 11.4 ± 1.8 mm, respectively.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081, and 31400303), and the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd. (Nos. 2015539200340277 and 2016JC03).

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Authors and Affiliations

  1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 650500, Kunming, P. R. China

    Shan-Shan Hu, Meng-Jie Liang, Guang-Yu Yang & Ya-Dong Guo

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, 650231, Kunming, P. R. China

    Qi-Li Mi, Wei Chen, Jun Ling, Xing Chen, Jing Li, Qiu-Fen Hu & Wei-Guang Wang

  3. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Guang-Yu Yang, Qiu-Fen Hu & Wei-Guang Wang

Authors
  1. Shan-Shan Hu
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  2. Meng-Jie Liang
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  3. Qi-Li Mi
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  4. Wei Chen
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  9. Qiu-Fen Hu
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  10. Wei-Guang Wang
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  11. Ya-Dong Guo
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Corresponding authors

Correspondence to Wei-Guang Wang or Ya-Dong Guo.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 727–729.

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Hu, SS., Liang, MJ., Mi, QL. et al. Two New Diphenyl Ether Derivatives from the Fermentation Products of the Endophytic Fungus Phomopsis asparagi. Chem Nat Compd 55, 843–846 (2019). https://doi.org/10.1007/s10600-019-02828-y

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  • DOI: https://doi.org/10.1007/s10600-019-02828-y

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