Extensive chromatographic purification of the chloroform–methanol (1:1) extract of the lichen Parmotrema mesotropum led to the isolation of methyl hematommate (1), methyl-2,4-dihydroxy-3,6-dimethylbenzoate (2), orcinol (3), and atranorin (4). The two major metabolites (1 and 2) were subjected to chemical modification and a total of 15 analogues were synthesized. The synthesized analogues and their parent compounds were evaluated for their anticancer potential against a panel of five human cancer cell lines. Among the tested samples, compound 1g showed potent activity against three cancer cell lines, namely DU145 (IC50 20.07 μM), MCF-7 (IC50 20.94 μM), and U87MG (IC50 25.32 μM). This compound can be considered as lead a molecule for further development.
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Acknowledgment
We are thankful to the Director of CSIR-IICT for keen interest and encouragement. We are also thankful to CSIR, New Delhi for the award of a research fellowship to one of us (RST).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2019, pp. 711–716.
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Mallavadhani, U.V., Tirupathamma, R.S., Sagarika, G. et al. Isolation, Chemical Modification, and Anticancer Activity of Major Metabolites of the Lichen Parmotrema mesotropum. Chem Nat Compd 55, 825–831 (2019). https://doi.org/10.1007/s10600-019-02824-2
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DOI: https://doi.org/10.1007/s10600-019-02824-2