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Synthesis of a 1,2,3-Thiadiazole of Butyl Glycyrrhetinate

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Chemistry of Natural Compounds Aims and scope

The butyl ester of 3-oxoglycyrrhetinic acid reacted with semicarbazide in EtOH in the presence of NaOAc to produce the 3-semicarbazone, Hurd–Mori cyclization of which gave in 85% yield a 1,2,3-thiadiazole annelated to ring A.

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Acknowledgment

The work was financially supported by Grant RFBR-MNT_a 18-53-52004 using equipment at the Khimiya CUC, UfIC, UFRC, RAS.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Subdivision of Ufa Federal Research Centre, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, Russian Federation, 450054

    L. A. Baltina, L. A. Baltina Jr. & T. R. Nugumanov

  2. Bashkir State University, 32 Zaki Validi St., Ufa, Russian Federation, 450076

    D. M. Shayakhmetova

Authors
  1. L. A. Baltina
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  2. D. M. Shayakhmetova
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  3. L. A. Baltina Jr.
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  4. T. R. Nugumanov
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Correspondence to L. A. Baltina.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 591–593.

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Baltina, L.A., Shayakhmetova, D.M., Baltina, L.A. et al. Synthesis of a 1,2,3-Thiadiazole of Butyl Glycyrrhetinate. Chem Nat Compd 55, 692–695 (2019). https://doi.org/10.1007/s10600-019-02780-x

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  • DOI: https://doi.org/10.1007/s10600-019-02780-x

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