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Chemistry of Natural Compounds

, Volume 55, Issue 4, pp 692–695 | Cite as

Synthesis of a 1,2,3-Thiadiazole of Butyl Glycyrrhetinate

  • L. A. BaltinaEmail author
  • D. M. Shayakhmetova
  • L. A. BaltinaJr.
  • T. R. Nugumanov
Article
  • 15 Downloads

The butyl ester of 3-oxoglycyrrhetinic acid reacted with semicarbazide in EtOH in the presence of NaOAc to produce the 3-semicarbazone, Hurd–Mori cyclization of which gave in 85% yield a 1,2,3-thiadiazole annelated to ring A.

Keywords

triterpenoids glycyrrhetinic acid semicarbazone thiadiazole 

Notes

Acknowledgment

The work was financially supported by Grant RFBR-MNT_a 18-53-52004 using equipment at the Khimiya CUC, UfIC, UFRC, RAS.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • L. A. Baltina
    • 1
    Email author
  • D. M. Shayakhmetova
    • 2
  • L. A. BaltinaJr.
    • 1
  • T. R. Nugumanov
    • 1
  1. 1.Ufa Institute of Chemistry, Subdivision of Ufa Federal Research CentreRussian Academy of SciencesUfaRussian Federation
  2. 2.Bashkir State UniversityUfaRussian Federation

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