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A New Totarane Diterpenoid from the Rhizomes of Isodon lophanthoides

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Chemistry of Natural Compounds Aims and scope

A new totarane diterpenoid, 7β,15-dihydroxytotarol-19-oic acid (1), along with six known diterpenoids (2–7) and seven known triterpenoids (8–14), were isolated from the EtOAc-soluble fraction of the 70% acetone extract of rhizomes of Isodon lophanthoides. Their structures were elucidated based on the analysis of extensive spectroscopic data. The antimalarial activities of all the isolated diterpenoids were measured by the β-hematin formation inhibition assay in vitro. Compounds 2 and 4 showed moderate activities.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 81460532 and 81641187).

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Authors and Affiliations

  1. College of Pharmacy and Chemistry, Dali University, 671000, Dali, P. R. China

    Wei Xu, Chao-Jiang Xiao, Jun-Zhe Sun, Pan-Pan Zhang, Jing-Wen Wang, Xiang Dong & Bei Jiang

  2. Institute of Materia Medica, Dali University, 671000, Dali, P. R. China

    Chao-Jiang Xiao, Xiang Dong & Bei Jiang

Authors
  1. Wei Xu
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  2. Chao-Jiang Xiao
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  3. Jun-Zhe Sun
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  4. Pan-Pan Zhang
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  5. Jing-Wen Wang
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  6. Xiang Dong
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  7. Bei Jiang
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Correspondence to Bei Jiang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2019, pp. 586–588.

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Xu, W., Xiao, CJ., Sun, JZ. et al. A New Totarane Diterpenoid from the Rhizomes of Isodon lophanthoides. Chem Nat Compd 55, 685–688 (2019). https://doi.org/10.1007/s10600-019-02778-5

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  • DOI: https://doi.org/10.1007/s10600-019-02778-5

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