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Two New Diphenyl Ether Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii

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Chemistry of Natural Compounds Aims and scope

Two new diphenyl ethers, 1-[2-methoxy-4-(3-methoxy-5-methylphenoxy)-6-methylphenyl]-ethanone (1) and 1-[4-(3-(hydroxymethyl)-5-methoxyphenoxy)-2-methoxy-6-methylphenyl]-ethanone (2), together five known diphenyl ether derivatives (3–7), were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. Compounds 1 and 2 showed good inhibition with IZD of 13.8 ± 1.5 mm and 14.6 ± 1.6 mm, respectively.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081, and 31400303), the Research Foundation of China Tobacco Company (No. 110201502006), and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (Nos. 2015539200340277 and 2016JC03).

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Hai-Ying Yang, Min Zhou, Guang-Yu Yang & Qiu-Fen Hu

  2. Research and Development of Center, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Yan-Qing Duan, Ye-Kun Yang, Xin Liu, Lin Ye, Qi-Li Mi, Wei-Song Kong, Guang-Yu Yang, Xue-Mei Li & Jing Li

Authors
  1. Hai-Ying Yang
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  2. Yan-Qing Duan
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  3. Ye-Kun Yang
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  4. Xin Liu
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  5. Lin Ye
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  8. Min Zhou
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  9. Guang-Yu Yang
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  10. Qiu-Fen Hu
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  11. Xue-Mei Li
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  12. Jing Li
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Corresponding authors

Correspondence to Xue-Mei Li or Jing Li.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2019, pp. 366–369.

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Yang, HY., Duan, YQ., Yang, YK. et al. Two New Diphenyl Ether Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii. Chem Nat Compd 55, 428–431 (2019). https://doi.org/10.1007/s10600-019-02706-7

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  • DOI: https://doi.org/10.1007/s10600-019-02706-7

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