A new triterpenoid, methyl 2α-O-trans-feruloyl-3β-hydroxy-urs-12-en-28-oate (1), has been isolated from the leaves of Eriobotrya deflexa f. buisanensis, together with five known compounds, methyl ursolate (2), oleanolic acid (3), corosolic acid (4), 3-O-trans-caffeoyltormentic acid (5), and tormentic acid (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, oleanolic acid (3), corosolic acid (4), and tormentic acid (6) showed potent inhibition with IC50 values of 16.3 ± 1.8, 20.4 ± 2.2, and 18.3 ± 1.4 μM, respectively, against LPS-induced NO generation. In addition, 3-O-trans-caffeoyltormentic acid (5) exhibited anti-Dengue virus activity with IC50 value of 12.4 ± 1.1 μM against Dengue virus serotype 2 strain PL046.
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Acknowledgment
This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 106-2320-B-010-033-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from Pingtung Christian Hospital (PS 106022), Kaohsiung Municipal United Hospital (KMUH-10612), and Zuoying Branch of Kaohsiung Armed Forces General Hospital (ZBH 106-24 and ZBH 106-25). Jih-Jung Chen, Ru-Fang Wu, Jen-Wen Hsiao, and Li-Chai Chen have contributed equally in this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2019, pp. 65–68.
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Chen, JJ., Wu, RF., Hsiao, JW. et al. A New Triterpenoid and Bioactive Constituents of Eriobotrya deflexa f. buisanensis. Chem Nat Compd 55, 74–78 (2019). https://doi.org/10.1007/s10600-019-02616-8
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DOI: https://doi.org/10.1007/s10600-019-02616-8