The total synthesis of a naturally occurring proline-enriched cyclic octapeptide, reniochalistatin E, from a marine sponge, where all the amino acids have the L-configuration, was reported. The reniochalistatin E was synthesized by applying a two-step solid-phase/solution synthesis strategy. The linear octapeptide was assembled by standard Fmoc chemistry on the solid phase, and subsequently cyclization was achieved by a solution method. The final product was purified by a preparative RP-HPLC system, and its structure was identified by HR-QTOF-MS, and 1H and 13C NMR.
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Acknowledgment
This research was supported by NSFC-Shandong Joint Fund (U1406402) and Innovation Project of Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02), and we are grateful to the Instrumental Analysis Center of Ocean University of China for NMR spectroscopic and mass spectrometric analysis.
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2018, pp. 962–964.
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Li, Yl., Chang, Q., Han, Ww. et al. Total Synthesis of Cyclic Octapeptide Reniochalistatin E. Chem Nat Compd 54, 1131–1134 (2018). https://doi.org/10.1007/s10600-018-2572-z
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DOI: https://doi.org/10.1007/s10600-018-2572-z