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A New Steroid Ester from the Leaves of Melia azedarach

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Chemistry of Natural Compounds Aims and scope

A new pregnane-type steroid, 2α,3β,16β-trihydroxy-5α-pregnane-20R-methacrylate (1), was isolated from the leaves of Melia azedarach, together with 17 known compounds. Their structures were elucidated by spectroscopic and mass-spectrometric analysis, including 1D, 2D NMR, ESI-MS, and HR-MS. Compound 1 was found to possess cytotoxicities against HepG2, K562, and SGC7901 cell lines, with IC50 values 18.6, 19.1, and 62.9 μM, respectively.

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Acknowledgment

This work was supported by grants from the Natural Science Foundation of Fujian Province (No. 2016J01369), the Open Project of National Marine Bureau Key Laboratory of Marine Biogenetic Resources (HY201506, HY201604), and the Startup Fund for scientific research, Fujian Medical University (2016QH015). The authors are grateful to State Key Laboratory of Applied Organic Chemistry at Lanzhou University for measuring of NMR and mass spectra.

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Authors and Affiliations

  1. Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 350004, Fuzhou, P. R. China

    Xinhua Ma, Fang Zhou, Yanping Deng, Kaihui Sun, Haitao Zhang, Xianming Zeng, Yonghong Zhang & Xiangbin Yu

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  1. Xinhua Ma
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  2. Fang Zhou
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  3. Yanping Deng
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  4. Kaihui Sun
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  5. Haitao Zhang
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  6. Xianming Zeng
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  7. Yonghong Zhang
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  8. Xiangbin Yu
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Corresponding author

Correspondence to Xiangbin Yu.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2018, pp. 781–784.

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Ma, X., Zhou, F., Deng, Y. et al. A New Steroid Ester from the Leaves of Melia azedarach. Chem Nat Compd 54, 921–925 (2018). https://doi.org/10.1007/s10600-018-2513-x

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  • DOI: https://doi.org/10.1007/s10600-018-2513-x

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