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Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

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Chemistry of Natural Compounds Aims and scope

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.

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Acknowledgment

The research was sponsored by a Grant of the Russian Science Foundation (Project No. 16-13-10074). We thank the Khimiya Common Use Center of NIOCh SB RAS for taking the spectral and analytical measurements.

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Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 8 Prosp. Acad. Lavrent’eva, Novosibirsk, 630090, Russia

    A. L. Zakharenko & O. I. Lavrik

  2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 9 Prosp. Acad. Lavrent’eva, Novosibirsk, 630090, Russia

    E. S. Mozhaitsev, E. V. Suslov, D. V. Korchagina, K. P. Volcho & N. F. Salakhutdinov

  3. Novosibirsk State University, 2 Pirogova St., Novosibirsk, 630090, Russia

    K. P. Volcho, N. F. Salakhutdinov & O. I. Lavrik

Authors
  1. A. L. Zakharenko
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  2. E. S. Mozhaitsev
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  3. E. V. Suslov
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  4. D. V. Korchagina
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  5. K. P. Volcho
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  6. N. F. Salakhutdinov
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  7. O. I. Lavrik
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Corresponding author

Correspondence to E. V. Suslov.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2018, pp. 569–572.

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Zakharenko, A.L., Mozhaitsev, E.S., Suslov, E.V. et al. Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). Chem Nat Compd 54, 672–676 (2018). https://doi.org/10.1007/s10600-018-2443-7

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  • DOI: https://doi.org/10.1007/s10600-018-2443-7

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