Secondary Metabolites Isolated from the Soft Coral-Derived Fungus Aspergillus sp. from the South China Sea
- 41 Downloads
Marine natural products have proven to be rich sources of structurally novel and biologically active compounds that have become significant chemical entities for drug discovery [1, 2]. To date, there are seven marine natural products and 13 marine-natural-products-inspired compounds that are FDA-approved agents or in clinical trial . Microorganisms derived from the marine environment play an important role in the discovery and development of marine drugs used to treat various diseases [4, 5]. As part of our ongoing investigation of marine bioactive compounds from the coral-derived fungus [6, 7, 8], six known compounds of diphenyl derivatives (1–6) were isolated for the first time from the soft coral Sinularia sp. derived fungus Aspergillus sp. collected from the South China Sea. Herein, we report the isolation, structure elucidation, and biological activity of these compounds (1–6).
The structures of compounds 1–6 were determined as methyl chloroasterrate (1) , methyl...
This work was supported by the Program of Natural Science Foundation of Shandong Province of China (No. JQ201510), Marine Special Public Welfare Scientific Research, State Oceanic Administration of China (No. 201405038), Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, and the Taishan Scholars Program, China.