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New Triterpenoid Saponin C-20 Epimers from the Alkaline-Degradation Products of Ginsenoside Re and Their Cytotoxic Activities

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Nine compounds, including two new triterpenoid saponin C-20 epimers (4 and 5) and seven known ginsenosides (1–3, 6–9), have been isolated and purified from the alkaline-degradation products of ginsenoside Re. Their structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS. Among them, (20S,22E)-6-O-β-D-glucopyranosyl-dammar-22(23),24-diene-3β,6α,12β-triol (4) and (20R,22E)-6-O-β-D-glucopyranosyl-dammar-22(23),24-diene-3β,6α,12β-triol (5) were identified as new triterpenoid saponins and they were assayed for cytotoxic activities against five human tumor cell lines.

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Acknowledgment

The authors are grateful to the State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, University of Jilin at Changchun for access to the Bruker AVANCE-500 NMR instrument for this study. The other chemical analysis was provided by the Alan. G. MacDiarmid Laboratory of Jilin University.

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Authors and Affiliations

  1. Department of Chemistry, Jilin University, Changchun, 130021, Jilin, P. R. China

    Hongda Ding, Zhicai Wang, Pengfei Zhang, Yan Xu, Manman Li & Yanping Chen

  2. Department of Pharmacology, College of Basic Medicine, Jilin University, Changchun, 130021, Jilin, P. R. China

    Xia Chen

  3. Yisheng Pharmaceutical Co., Ltd., Ji′an, 134200, Jilin, P. R. China

    Fangfei Xu

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  1. Hongda Ding
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  2. Zhicai Wang
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  4. Pengfei Zhang
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  5. Fangfei Xu
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  6. Yan Xu
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  7. Manman Li
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  8. Yanping Chen
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Correspondence to Yanping Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2018, pp. 416–419.

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Ding, H., Wang, Z., Chen, X. et al. New Triterpenoid Saponin C-20 Epimers from the Alkaline-Degradation Products of Ginsenoside Re and Their Cytotoxic Activities. Chem Nat Compd 54, 490–495 (2018). https://doi.org/10.1007/s10600-018-2386-z

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  • DOI: https://doi.org/10.1007/s10600-018-2386-z

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