Chemistry of Natural Compounds

, Volume 54, Issue 3, pp 471–474 | Cite as

Terpenoids from Tripterygium hypoglaucum and Their Anti-Inflammatory Activity

  • Qun Zhao
  • Hong-Mei Li
  • Xuan-Qin Chen
  • Rong-Tao Li
  • Dan Liu

A new diterpenoid, 19-O-β-D-glucopyranosyl-labda-8(17),14-dien-13-ol (1), and nine known triterpenes (2–10) were isolated from the aerial parts of Tripterygium hypoglaucum. All structures were elucidated by NMR spectroscopic methods. Moreover, the inhibition of superoxide anion generation and elastase release were also examined.


Tripterygium hypoglaucum Celastraceae diterpenoid anti-inflammatory 



Financial support from the National Natural Science Foundation of China (Nos. 21262021 and 31660102) is acknowledged. We also wish to thank Prof. Tsong-long Hwang (Graduate Institute of Natural Products, College of Medicine, Chang Gung University) for his help in the biological assays.


  1. 1.
    Editorial Board of Flora of China, Flora of China (2005 Ed.), Vol. 45 (3), Science Press, Beijing, 2005, p. 178.Google Scholar
  2. 2.
    A. M. Brinker, J. Ma, P. E. Lipsky, and I. Raskin, Phytochemistry, 68, 732 (2007).CrossRefPubMedGoogle Scholar
  3. 3.
    J. Ma, M. Dey, H. Yang, A. Poulev, R. Pouleva, R. Dorn, P. E. Lipsky, E. J. Kennelly, and I. Raskin, Phytochemistry, 68, 1172 (2007).CrossRefPubMedGoogle Scholar
  4. 4.
    H. Q. Duan, Y. Takaishi, H. Momota, Y. Ohmoto, T. Taki, Y. F. Jia, and D. Li, J. Nat. Prod., 62, 1522 (1999).CrossRefPubMedGoogle Scholar
  5. 5.
    H. Q. Duan, Y. Takaishi, H. Momota, Y. Ohmoto, T. Taki, Y. F. Jia, and D. Li, Phytochemistry, 53, 805 (2000).CrossRefPubMedGoogle Scholar
  6. 6.
    H. Q. Duan, Y. Takaishi, H. Momota, Y. Ohmoto, T. Taki, M. Tori, S. Takaoka, Y. Jia, and D. Li, Tetrahedron, 57, 8413 (2001).CrossRefGoogle Scholar
  7. 7.
    H. Q. Duan, Y. Takaishi, H. Momota, Y. Ohmoto, T. Taki, M. Tori, S. Takaoka, Y. Jia, and D. Li, J. Nat. Prod., 64, 582 (2001).CrossRefPubMedGoogle Scholar
  8. 8.
    J. Bao and S. M. Dai, Rheumatol. Int., 31, 1123 (2011).CrossRefPubMedGoogle Scholar
  9. 9.
    H. Z. Li, L. Z. Fu, H. M. Li, R. T. Li, and X. L. Deng, Phytochem. Lett., 5, 572 (2012).CrossRefGoogle Scholar
  10. 10.
    A. Ulubelen, G. Topcu, C. Eris, U. Soenmez, M. Kartal, S. Kurucu, and C. Bozok-Johansson, Phytochemistry, 36, 971 (1994).CrossRefPubMedGoogle Scholar
  11. 11.
    J. Hu, X. Q. Chen, and Q. S. Zhao, Helv. Chim. Acta, 94, 1085 (2011).CrossRefGoogle Scholar
  12. 12.
    J. J. Li, J. Yang, F. Lu, Y. T. Qi, Y. Q. Liu, Y. Sun, and Q. Wang, Chin. J. Nat. Med., 10, 279 (2012).CrossRefGoogle Scholar
  13. 13.
    H. Kizu and T. Tomimori, Chem. Pharm. Bull., 30, 3340 (1982).CrossRefGoogle Scholar
  14. 14.
    J. Y. Zhou and R. Cui, Acta Pharm. Sin., 37, 633 (2002).Google Scholar
  15. 15.
    G. W. Qin, X. M. Yang, W. H. Gu, B. D. Wang, Z. X. Chen, R. X. Guo, and K. W. Shao, Huaxue Xuebao, 40, 637 (1982).Google Scholar
  16. 16.
    C. Djerassi, J. A. Henry, A. Lemin, T. Rios, and G. H. Thomas, J. Am. Chem. Soc., 78, 3783 (1956).CrossRefGoogle Scholar
  17. 17.
    D. Caceres-Castillo, G. J. Mena-Rejon, R. Cedillo-Rivera, and L. Quijano, Phytochemistry, 69, 1057 (2008).CrossRefPubMedGoogle Scholar
  18. 18.
    X. L. Fu, L. W. Zhang, W. H. Lin, and Q. S. Li, Zhongcaoyao, 41, 704 (2010).Google Scholar
  19. 19.
    S. Hara, H. Okabe, and K. Mihashi, Chem. Pharm. Bull., 35, 501 (1987).CrossRefGoogle Scholar
  20. 20.
    S. C. Yang, P. J. Chung, C. M. Ho, C. Y. Kuo, M. F. Hung, Y. T. Huang, W. Y. Chang, Y. W. Chang, K. H. Chan, and T. L. Hwang, J. Immunol., 190, 6511 (2013).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Qun Zhao
    • 1
  • Hong-Mei Li
    • 1
  • Xuan-Qin Chen
    • 1
  • Rong-Tao Li
    • 1
  • Dan Liu
    • 1
  1. 1.Faculty of Life Science and TechnologyKunming University of Science and TechnologyKunmingP. R. China

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