Chemistry of Natural Compounds

, Volume 54, Issue 3, pp 443–446 | Cite as

Four Major Urinary Metabolites of Liquiritigenin in Rats and Their Anti-Platelet Aggregation Activity

  • Yuan-yuan Li
  • Long Yang
  • Xin Chai
  • Jun-jun Yang
  • Yue-fei Wang
  • Yan Zhu

Urinary metabolites of liquiritigenin were investigated in rats after intravenous administration. Four major urinary metabolites, isoliquiritigenin (2), liquiritigenin-4′-O-β-D-glucuronide (3), liquiritigenin-7-O-β-Dglucuronide (4), and davidigenin-2′-O-β-D-glucuronide (5), were isolated from the urine of rats. Their structures were elucidated on the basis of extensive spectroscopic methods, among which 5 was a new compound. Compound 2 showed significant inhibition of platelet aggregation induced by ADP, whose 50% inhibitory concentration (IC50) value was 20.38 ± 1.68 μM.


liquiritigenin metabolites inhibition of platelet aggregation 



This work was financially supported by the National Natural Science Foundation of China (Grant numbers 81403060 and 81202877).


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Authors and Affiliations

  1. 1.Tianjin State Key Laboratory of Modern Chinese MedicineTianjin University of Traditional Chinese MedicineTianjinP. R. China
  2. 2.Tianjin Key Laboratory of TCM Chemistry and AnalysisTianjin University of Traditional Chinese MedicineTianjinP. R. China

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