Four Major Urinary Metabolites of Liquiritigenin in Rats and Their Anti-Platelet Aggregation Activity
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Urinary metabolites of liquiritigenin were investigated in rats after intravenous administration. Four major urinary metabolites, isoliquiritigenin (2), liquiritigenin-4′-O-β-D-glucuronide (3), liquiritigenin-7-O-β-Dglucuronide (4), and davidigenin-2′-O-β-D-glucuronide (5), were isolated from the urine of rats. Their structures were elucidated on the basis of extensive spectroscopic methods, among which 5 was a new compound. Compound 2 showed significant inhibition of platelet aggregation induced by ADP, whose 50% inhibitory concentration (IC50) value was 20.38 ± 1.68 μM.
Keywordsliquiritigenin metabolites inhibition of platelet aggregation
This work was financially supported by the National Natural Science Foundation of China (Grant numbers 81403060 and 81202877).
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