Chemical Constituents of the Fungus Mycoleptodiscus sp. 09F0149
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During a program of investigation on potentially bioactive secondary metabolites from Formosan endemic plant endophytes, an endophytic fungal strain, Mycoleptodiscus sp. (Magnaporthaceae) BCRC 09F0149, was isolated from the root of Piper sintenense Hatus. (Piperaceae). Previous chemical investigations of the genus Mycoleptodiscus have received less attention, and only a few articles have been reported [1, 2, 3]. In the course of our search for potentially diverse secondary metabolites from natural fungal sources, we have investigated the minor metabolites of the genus Mycoleptodiscus and examined the EtOAc-soluble fraction of Mycoleptodiscussp. Current phytochemical investigation of the above-mentioned fungus has led to the isolation of seven metabolites, including two known aliphatics, one benzenoid, and four known steroids. The structures of the isolated metabolites were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports....
This investigation was supported by a grant from the Ministry of Economic Affairs of the Republic of China. The authors also thank Senior Technician Mrs. Chyi-Jia Wang of the Center for Resources, Research and Development (CRRD) of Kaohsiung Medical University for measuring the 2D NMR data.
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