Advertisement

Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 373–374 | Cite as

Hydrophobic Isoprenoids from Stems of Astragalus galegiformis from the Flora of Georgia

  • M. D. Alaniya
  • M. G. Sutiashvili
Article
  • 22 Downloads

Previously, we reported the isolation of flavonoids and cycloartanes from the aerial parts of Astragalus galegiformis L. (Leguminosae L.) [1, 2, 3]. Leaves and flowers of the plant contained flavonoids as oligosides of kaempferol, quercetin, and isorhamnetin [1]. Stems were dominated by cycloartanes, i.e., cyclogalegigenin derivatives (0.35–0.5% yield of raw material mass), that exhibited cardiotonic and hypocholesterolemic activity [4].

In continuation of research on isoprenoids from this plant, we studied compounds extracted by CHCl3 from the aqueous alcohol extract. Air-dried ground stems (0.326 kg) that were collected during full bloom in the vicinity of Tbilisi (Georgia) were exhaustively extracted with EtOH (75%). The EtOH was evaporated. The residue was extracted with CHCl3 (4 × 200 mL). The CHCl3was evaporated. The residue (120 g) was dissolved in a small amount of MeOH and reprecipitated by hot water. The mixture was cooled and filtered. The filtrate was condensed to a dry...

References

  1. 1.
    M. D. Alaniya, N. Sh. Kavtaradze, C. Bassarello, A. V. Skhirtladze, and C. Pizza, Chem. Nat. Compd., 42, 681 (2006).CrossRefGoogle Scholar
  2. 2.
    M. D. Alaniya, M. I. Isaev, M. B. Gorovits, N. D. Abdullaev, E. P. Kemertelidze, and N. K. Abubakirov, Chem. Nat. Compd., 20, 451 (1984).CrossRefGoogle Scholar
  3. 3.
    M. D. Alaniya, T. I. Gigoshvili, and N. Sh. Kavtaradze, Chem. Nat. Compd., 42, 310 (2006).CrossRefGoogle Scholar
  4. 4.
    M. D. Alania, Advances in the Chemistry of Secondary Metabolites (Flavonoids and Cycloartans) of Astragalus from Georgia’s Flora [in Russian], Samshoblo, Tbilisi, 2016, 394 pp.Google Scholar
  5. 5.
    I. M. Isaev, R. P. Mamedova, M. A. Agzamova, and M. I. Isaev, Chem. Nat. Compd., 43, 358 (2007).CrossRefGoogle Scholar
  6. 6.
    P. K. Agraval and R. P. Rastogi, Heterocycles, 16 (12), 2181 (1981).CrossRefGoogle Scholar
  7. 7.
    M. D. Alaniya, N. Sh. Kavtaradze, R. Faure, and L. Debrauwer, Chem. Nat. Compd., 44, 324 (2008).CrossRefGoogle Scholar
  8. 8.
    E. Onoja and I. G. Ndukwe, J. Nat. Prod. Plant Resour., 3 (2), 57 (2013).Google Scholar
  9. 9.
    W. Seebacher, N. Simic, R. Weis, R. Saf, and O. Kunert, Magn. Reson. Chem., 41, 636 (2003).CrossRefGoogle Scholar
  10. 10.
    V. S. P. Chaturvedula and I. Prakash, Int. Curr. Pharm. J., 1 (9), 239 (2012).CrossRefGoogle Scholar
  11. 11.
    A. N. Svechnikova, R. U. Umarova, N. D. Abdullaev, M. B. Gorovits, T. T. Gorovits, and N. K. Abubakirov, Chem. Nat. Compd., 19, 432 (1983).CrossRefGoogle Scholar
  12. 12.
    J. Wang, H. Xu, W. Li, Z. Hua, and S. Zhan, Zhongguo Zhongyao Zazhi, 33 (4), 414 (2008).PubMedGoogle Scholar
  13. 13.
    M. D. Alaniya, M. G. Sutiashvili, N. Sh. Kavtaradze, and A. V. Skhirtladze, Chem. Nat. Compd., 53, 1202 (2017).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.I. G. Kutateladze Institute of PharmacochemistryTbilisi State Medical UniversityTbilisiGeorgia

Personalised recommendations