Hydrophobic Isoprenoids from Stems of Astragalus galegiformis from the Flora of Georgia
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Previously, we reported the isolation of flavonoids and cycloartanes from the aerial parts of Astragalus galegiformis L. (Leguminosae L.) [1, 2, 3]. Leaves and flowers of the plant contained flavonoids as oligosides of kaempferol, quercetin, and isorhamnetin . Stems were dominated by cycloartanes, i.e., cyclogalegigenin derivatives (0.35–0.5% yield of raw material mass), that exhibited cardiotonic and hypocholesterolemic activity .
In continuation of research on isoprenoids from this plant, we studied compounds extracted by CHCl3 from the aqueous alcohol extract. Air-dried ground stems (0.326 kg) that were collected during full bloom in the vicinity of Tbilisi (Georgia) were exhaustively extracted with EtOH (75%). The EtOH was evaporated. The residue was extracted with CHCl3 (4 × 200 mL). The CHCl3was evaporated. The residue (120 g) was dissolved in a small amount of MeOH and reprecipitated by hot water. The mixture was cooled and filtered. The filtrate was condensed to a dry...
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