Effective Synthetic Method and Rotameric Isomerization of 2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Maleopimarate
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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2018, pp. 308–309.
Maleopimaric acid and its derivatives exhibit potent biological activities, in particular, antiviral, antibacterial, cytotoxic, antitumor, and antiulcerogenic [1, 2, 3, 4, 5]. Proposed thermal-activation approaches to synthesizing N-imides of the methyl ester of maleopimaric acid (MEMPA) did not always lead to the target products and acceptable MEMPA conversion [6, 7, 8, 9]. Herein, we communicate an effective synthetic method for N-maleopimarimide-substituted 5-aminouracil using ultrasound irradiation in dimethylsulfoxide (DMSO).
The work was performed according to planned scientific research at Ufa Institute of Chemistry, RAS, on the topic “Synthesis of biologically active heterocyclic and terpenoid compounds” (State Reg. No. AAAA-A17-117011910025-6). Information support came from RFBR Grant 13-00-14056. The spectral studies used equipment at the Khimiya CCU, UfIC, RAS.
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