Diterpenoids and Flavonoids from Pulicaria gnaphalodes
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The plant Pulicaria gnaphalodes (Asteraceae) is broadly distributed in Central Asia and is used in folk medicine as an antifungal agent. Previously, we isolated and identified 25 compounds such as diterpenoids, coumarins, sterols, and phenolic compounds from the aerial part of the plant collected in Tashkent Oblast (Uzbekistan) [1, 2, 3, 4].
Research on the chemical composition of the aerial part of P. gnaphalodes [2, 3, 4] continued with column chromatography over silica gel and Sephadex LH-20 of the CHCl3 and n-BuOH fractions with elution by gradients of hexane–EtOAc (10:1–1:1), CHCl3–MeOH (20:1–1:1), and MeOH–H2O (6:4) to isolate six diterpenoid and flavonoid compounds.
The chemical structures of the isolated compounds were identified based on PMR, 13C NMR, and 2D experiments in addition to comparisons with the literature.
Salvin (1), C20H26O3. 1H NMR spectrum (400 MHz, CDCl3, δ, ppm, J/Hz): 0.88 (3H, s, CH3-20), 1.01 (3H, d, J = 6.1, CH3-17), 1.04 (3H, s, CH3-19), 1.27 (1H, m,...
The work was financially supported by the Program of Applied Scientific Research of the AS, RUz (Grant FA-A11-T040), Foundations and Programs for International Scientific and Technical Collaboration Projects (Grant No. 2016YFE0120600), and the Central Asia Drug Research and Development Center of the Chinese Academy of Sciences.
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