Advertisement

Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 356–357 | Cite as

Chemical Constituents of the Stems of Spatholobus parviflorus and Their Cholinesterase Inhibitory Activity

  • Jirapast Sichaem
  • Thanatip Ruksilp
  • Pattara Sawasdee
  • Suttira Khumkratok
  • Santi Tip-pyang
Article

Spatholobus parviflorus (Fabaceae), locally known as “Tao Pun Sai,” is a strong and woody climber. It is widely distributed in many parts of Thailand. An ethnobotanical use of this species by tribesmen in the North is as a medicinal plant to treat rheumatism, anemia, and other diseases. In previous work, the active constituents of the leaves of S. parviflorus were reported [1]. However, to our knowledge the chemical constituents of S. parviflorus stems have not been reported up to now. The stem extract of S. parviflorus was fractionated by a combination of silica gel column chromatography and centrifugal thin-layer chromatography to afford stigmasterol (1) [2], (6aR,11aR)-medicarpin (2) [3], 8-O-methylretusin (3) [4], formononetin (4) [5], biochanin A (5) [6], 7,4′-dihydroxy-8-methoxyisoflavone (6) [7], daidzein (7) [8], trans and cis-4-hydroxymelleins (8 and 9) [9], and coumestrol (10) [10], which were interpreted by spectroscopic analysis, particularly NMR and MS and coincided well...

Notes

Acknowledgment

The authors are grateful to the Graduate School of Chulalongkorn University for a Postdoctoral Fellowship (Ratchadaphiseksomphot Endowment Fund) to JS and the Thailand Research Fund via Directed Basic Research Grant (Grant No. DBG 5980001) for partial financial support. We also thank Dr. Christopher Smith of the Department of Chemistry, Faculty of Science, Chulalongkorn University, for his editorial comments.

References

  1. 1.
    M. Madhavan, Int. J, Pharnacogn. Phytochem. Res., 7, 991 (2015).Google Scholar
  2. 2.
    C. Y. Ragasa, O. B. Torres, C. C. Shen, L. O. Bernardo, E. H. Mandia, K. A. De Castro-Cruz, and P. W. Tsai, Chem. Nat. Compd., 50, 172 (2014).CrossRefGoogle Scholar
  3. 3.
    S. Y. Jeong, H. S. Sang, H. P. Jong, and C. K. Young, Arch. Pharm. Res., 27, 589 (2004).CrossRefGoogle Scholar
  4. 4.
    R. Y. Yang, Y. S. Lan, Z. J. Huang, C. L. Shao, H. Liang, Z.-F. Chen, and J. Li, Chem. Nat. Compd., 48, 674 (2012).CrossRefGoogle Scholar
  5. 5.
    H. E. Zhang and D. P. Xu, J. Chin. Med. Mater., 30, 164 (2007).Google Scholar
  6. 6.
    A. C. Talukdar, J. Jain, S. De, and H. G. Krishnamurty, Phytochemistry, 53, 155 (2000).CrossRefPubMedGoogle Scholar
  7. 7.
    H.-M. Shi, Z.-Q. Huang, J. Wen, and P.-F. Tu, Chin. J. Nat. Med., 4, 30 (2006).Google Scholar
  8. 8.
    F. Tosun, C. Akyuz Kizilay, and A. U. Tosun, Chem. Nat. Compd., 45, 83 (2009).CrossRefGoogle Scholar
  9. 9.
    K. N. Asha, R. Chowdhury, C. M. Hasan, and M. A. Rashid, Acta Pharm., 54, 57 (2004).PubMedGoogle Scholar
  10. 10.
    H. Koshino, Y. Masaoka, and A. Ichihara, Phytochemistry, 33, 1075 (1993).CrossRefGoogle Scholar
  11. 11.
    G. L. Ellman, D. Courtney, A. Valentino, and R. M. Featherstone, Biochem. Pharmacol., 7, 88 (1961).CrossRefPubMedGoogle Scholar
  12. 12.
    K. Ingkaninan, K. Changwijit, and K. Suwanborirux, J. Pharm. Pharmacol., 58, 847 (2006).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jirapast Sichaem
    • 1
  • Thanatip Ruksilp
    • 1
  • Pattara Sawasdee
    • 1
  • Suttira Khumkratok
    • 2
  • Santi Tip-pyang
    • 1
  1. 1.Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of ScienceChulalongkorn UniversityBangkokThailand
  2. 2.Walai Rukhavej Botanical Research InstituteMahasarakham UniversityMahasarakhamThailand

Personalised recommendations