Secondary Metabolites of an Endophytic Fungus Phomopsis castaneae-mollissimae
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Endophytic fungi are microorganisms that colonize the tissues of healthy plants without causing apparent harm . They are attracting attention as potential sources of novel and biologically active natural products . Endophytic Phomopsis species have gained attention in most cases involving metabolite research, which has led to the discovery of various bioactive secondary metabolites . In the course of our previous studies on the bioactivity of endophytic fungi from medicinal plants and their different solvent extracts, some endophytic fungi with various bioactivities have been isolated [4, 5]. As part of our systematic search for new bioactive compounds from endophytic fungi, the endophytic fungus Phomopsis castaneae-mollissimae, isolated from the traditional Chinese medicinal plant Artemisia annua, was selected for chemical and biological investigations. We have studied the secondary metabolites of this strain and obtained six compounds (1–6).
The fungal strain P....
This work was funded by the talent introduction plan of Guizhou University (No. 59), the joint funds plan of Guizhou Province (No. LH 7657) and the grants of the agricultural science and technology foundation of Guizhou Province (Nos. NY3042 and NY3044) from the Science and Technology Bureau of Guizhou University and the Science and Technology Department of Guizhou Province, China. The authors would also like to thank the National Natural Science Foundation of China (Nos. 31460011 and 31670027) for supporting and funding this research.
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