Addition of Cyanoethyl Groups to Ring a of Triterpenoids
- 41 Downloads
The potential for cyanoethylation of ring A of triterpenoids and their A-seco derivatives prepared from allobetulone and methyl betulonate was investigated. Triterpenoids with a cyanoethyl moiety on C-1, C-2, and C-3 and derivatives with two cyanoethyl groups on ring A were synthesized. The inhibitory activity of the synthesized compounds for herpes simplex virus type 1 was studied in vitro.
Keywordstriterpenoids A-seco-triterpenoids betulin cyanoethylation acrylonitrile antiviral activity herpes simplex virus type 1
The work was financially supported by the Government of Perm Krai in the framework of Science Project No. C-26/056, grants MK-5386.2016.3, RFBR No. 16-53-00029Bel_a and BRFBR No. M16R-012.
- 14.A. N. Volkova, “Synthesis of new N-containing lupane-type triterpenoids,” Candidate Dissertation, NIOCh, SB, RAS, Novosibirsk, 2014, 177 pp.Google Scholar
- 15.A. N. Antimonova, N. I. Petrenko, E. E. Shul’ts, and G. A. Tolstikov, in: Proceedings of the XIIIth Youth School-Conference “Critical Problems in Organic Chemistry” [in Russian], Novosibirsk, 2010, p.85.Google Scholar