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Two New Polyhydroxylated Sterol Derivatives from the Sponge Topsentia sp. Collected from the South China Sea

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Chemistry of Natural Compounds Aims and scope

Further chemical investigation of the marine sponge Topsentio sp. collected from the South China Sea led to the isolation of two new polyhydroxylated sterol derivatives, topsensterol D (1) and 4β-hydroxyhalistanol (2). Their structures were elucidated by detailed analysis of the spectroscopic data including 1D and 2D NMR spectral data. Their cytotoxic activities were evaluated.

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Acknowledgment

This work was supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No. 16KJB350005), the National Natural Science Foundation of China (Nos. 81703411, 41130858, and U1406402-1), the National High Technology Research and Development Program of China (863 Program) (2013AA093001), and the Taishan Scholars Program, China.

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Authors and Affiliations

  1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, 266003, Qingdao, P. R. China

    Min Chen, Xu-Dong Wu, Jun-Di Hao & Chang-Yun Wang

  2. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, 196#, Huayang West Street, 225127, Yangzhou, P. R. China

    Min Chen

Authors
  1. Min Chen
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  2. Xu-Dong Wu
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  3. Jun-Di Hao
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  4. Chang-Yun Wang
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Correspondence to Chang-Yun Wang.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2018, pp. 252–254.

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Chen, M., Wu, XD., Hao, JD. et al. Two New Polyhydroxylated Sterol Derivatives from the Sponge Topsentia sp. Collected from the South China Sea. Chem Nat Compd 54, 301–304 (2018). https://doi.org/10.1007/s10600-018-2328-9

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  • DOI: https://doi.org/10.1007/s10600-018-2328-9

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