New sulfides based on 4-caranethiol, 3-hydroxyisocaranethiol, neomenthanethiol, 10-thioisoborneol, 10-hydroxyisocamphenylthiol, and 10-thioisocampheol containing L-serine residues were synthesized for the first time in 40–70% yields. The synthesized compounds were not cytotoxic in a laboratory mouse erythrocyte hemolysis model and possessed statistically significant membrane-protective and antioxidant activity at a concentration of 50 μmol/L.
KeywordsS-monoterpenylcysteines 4-caranethiol 3-hydroxyisocaranethiol 10-hydroxyisocamphenylthiol neomenthanethiol L-serine L-3-chloroalanine sulfides antioxidant activity erythrocytes cytotoxicity
The work was financially supported by the RFBR (Project 16-03-01064) and used equipment at the Khimiya Center for Collective Use (CCU) at the Institute of Chemistry, Komi SC, UB, RAS. Antioxidant and membrane-protective activities were studied at the Molecular Biology CCU at the Institute of Biology, Komi SC, UB, RAS. Animals from the scientific collection of experimental animals at the Institute of Biology, Komi SC, UB, RAS were used in the work (http://www.ckp-rf.ru/usu/471933/).