Four Verrucosidin Derivatives Isolated from the Hydrothermal Vent Sulfur-Derived Fungus Penicillium sp. Y-50-10
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Four verrucosidin derivatives, penicyrone (1), norpenicyrone (2), methyl norpenicyrone (3), and methyl penicyrone (4) were isolated from the hydrothermal vent sulfur-derived fungus Penicillium sp. Y-50-10. Compounds 1–4 were obtained as a mixture of two epimers. Compounds 2–4 have been proved to be new secondary metabolites. The chemical structures were determined by comparing with literature data and HR-MS and 2D NMR spectroscopic analysis. The migration of the double bond from C8=C9 to C7=C8 in compounds 1–4 allowed the assignment of a rearranged verrucosidin skeleton. Compounds 1–4 showed activity against B. subtilis, with MIC values of 32 μg/mL.
Keywordsmarine fungus Penicillium sp. penicyrone
This work was supported by NSFC (Nos. 81273386 and 81573306).