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Two New Benzolactones from the Leaves of Yunnan Local Sun Cured Tobacco and Their Bioactivities

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Chemistry of Natural Compounds Aims and scope

Two new benzolactones, 4-methoxy-6-(2-oxopropyl)isobenzofuran-1(3H)-one (1) and 4-methyl-6-(2-oxopropyl)isobenzofuran-1(3H)-one (2), were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1 and 2 showed high anti-TMV activity with inhibition rates of 32.6 and 30.2%. These rates are close to that of positive control. Compounds 1 and 2 also showed weak inhibitory activities against some tested human tumor cell lines.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (No. 31360081), the Applied Fundamental Foundation of Yunnan Province (No. 2013FB097), and the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd. (2013FL05 and 2012JC01).

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Authors and Affiliations

  1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming, 650500, Yunnan, P. R. China

    Jianlian Shi, Xingmeng Xu & Yadong Guo

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Jianlian Shi, Xingmeng Xu, Chunbo Liu, Ling Ye, Fengmei Zhang, Pei He, Zhihua Liu, Mingming Miao, Shiyun Tang & Qinpeng Shen

  3. School of Chemical Science and Technology, Yunnan University, 650091, Kunming, P. R. China

    Peisong Yang

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  1. Jianlian Shi
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  2. Xingmeng Xu
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  3. Chunbo Liu
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  4. Ling Ye
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  5. Peisong Yang
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  9. Mingming Miao
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  11. Yadong Guo
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  12. Qinpeng Shen
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Corresponding authors

Correspondence to Yadong Guo or Qinpeng Shen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2018, pp. 199–201.

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Shi, J., Xu, X., Liu, C. et al. Two New Benzolactones from the Leaves of Yunnan Local Sun Cured Tobacco and Their Bioactivities. Chem Nat Compd 54, 238–241 (2018). https://doi.org/10.1007/s10600-018-2312-4

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  • DOI: https://doi.org/10.1007/s10600-018-2312-4

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