Sesquiterpene Lactones from Vernonia cinerea
A new hirsutinolide-type sesquiterpene lactone, 8α-(2′Z-tigloyloxy)-1α-methoxyhirsutinolide (1), and a new naturally occurring 8α-(2′-hydroxymethylacryloyloxy)-1α-methoxyhirsutinolide-13-O-acetate (2) were isolated from the CHCl3 extract of the aerial parts of Vernonia cinerea (Asteraceae). The structures of the new compounds were determined by 1D and 2D NMR and MS experiments, as well as by comparison of their data with the published values.
KeywordsVernonia cinerea Asteraceae sesquiterpene lactone
This research was supported by the National Institute of Minority Health and Health Disparities (NIMHD) of the National Institutes of Health under award number U54MD008149 (L.C.C). The content is solely the responsibility of the authors and does not necessarily represent the official view of NIMHD or NIH. This work was also supported by the Korea Polar Research Institute, KOPRI, under the project PE17100 (U.J.Y). We thank H. S. Shin, National Center for Inter-university Research Facilities, Seoul National University, for providing the mass spectrometry facility used in this study.
- 6.C. Gunasingh, G. Barnabas, and S. Nagarajan, Indian J. Pharm. Sci., 43, 114 (1981).Google Scholar